Thanks for your input AK. Maybe it is related to the settings in the feather files (DTS). Another user has reported the problem on a “Sparkfun nRF9160 Thing plus” with relative short instructions on how to reproduce (UDP sample and CONFIG_I2C=y added). If you have the time, please try and enable serial also on your thingy91 app. By the way, I just updated a Thingy91 with the latest asset tracker from Nordic, and it does run fine, and measurements are sent to nrfcloud.