Please, keep the SIM card slot, it’s anyway at the bottom, where space seems to be not an issue.
In my experience of the last year (switching frommfw 1.3.1 to 1.3.2 an get the HPPLMN search for 9xxxx networks when using global SIMs (IMSI starting with 9xxxx)), it’s very important to be able to exchange the SIM card.
Using eSIM or Soft SIM, will be great, but only if it really works for your use-case.